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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50296753
Substrate
n/a
Meas. Tech.
ChEMBL_582484 (CHEMBL1058161)
Ki
354±n/a nM
Citation
 O'Donnell, CJ; Peng, L; O'Neill, BT; Arnold, EP; Mather, RJ; Sands, SB; Shrikhande, A; Lebel, LA; Spracklin, DK; Nedza, FM Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 19:4747-51 (2009) [PubMed]  Article
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50296753
Synonyms:
4-(pyridin-2-yl)phenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate | CHEMBL551328
Type:
Small organic molecule
Emp. Form.:
C19H21N3O2
Mol. Mass.:
323.3889
SMILES:
O=C(Oc1ccc(cc1)-c1ccccn1)N1CCN2CCC1CC2 |TLB:1:15:20.19:22.23,(13.56,-25.18,;13.56,-26.75,;14.91,-27.54,;16.27,-26.75,;17.64,-27.55,;19.03,-26.76,;19.03,-25.16,;17.63,-24.36,;16.26,-25.16,;20.38,-24.37,;20.38,-22.83,;21.71,-22.07,;23.03,-22.83,;23.03,-24.36,;21.7,-25.14,;12.2,-27.54,;12.3,-29.09,;11.42,-28.18,;10,-28,;10.23,-26.25,;11.07,-25.19,;10.88,-26.64,;9.43,-27.13,;8.87,-28.55,)|
Structure:
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