Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50296751
Substrate
n/a
Meas. Tech.
ChEMBL_582484 (CHEMBL1058161)
Ki
207±n/a nM
Citation
 O'Donnell, CJPeng, LO'Neill, BTArnold, EPMather, RJSands, SBShrikhande, ALebel, LASpracklin, DKNedza, FM Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 19:4747-51 (2009) [PubMed]  Article
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50296751
Synonyms:
4-(pyridin-4-yl)phenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate | CHEMBL550460
Type:
Small organic molecule
Emp. Form.:
C19H21N3O2
Mol. Mass.:
323.3889
SMILES:
O=C(Oc1ccc(cc1)-c1ccncc1)N1CCN2CCC1CC2 |TLB:1:15:20.19:22.23,(-3.61,-32.7,;-3.61,-34.24,;-2.27,-35,;-.94,-34.24,;.42,-35.05,;1.8,-34.24,;1.8,-32.65,;.41,-31.87,;-.96,-32.66,;3.13,-31.88,;4.47,-32.65,;5.81,-31.88,;5.8,-30.35,;4.47,-29.57,;3.13,-30.35,;-4.94,-35,;-4.85,-36.56,;-5.73,-35.64,;-7.13,-35.47,;-6.92,-33.72,;-6.08,-32.68,;-6.26,-34.11,;-7.71,-34.6,;-8.27,-36.01,)|
Structure:
Search PDB for entries with ligand similarity: