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Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50297564
Substrate
n/a
Meas. Tech.
ChEMBL_583577 (CHEMBL1059092)
IC50
25.5±n/a nM
Citation
 Zhang, R; Dong, J; Xu, YG; Hua, WY; Wen, N; You, QD Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives. Eur J Med Chem 44:3771-6 (2009) [PubMed]  Article
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
NHE-1 | Na(+)/H(+) exchanger 1 | Nhe1 | SL9A1_RAT | Slc9a1 | Solute carrier family 9 member 1
Type:
PROTEIN
Mol. Mass.:
91655.00
Organism:
Rattus norvegicus
Description:
ChEMBL_862370
Residue:
820
Sequence:
MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTASTIRGSEPPRERSIGDVTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYEYVGISDIFLGFLSFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSAASERILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTDDVFTPGPSDSPGSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
  
Inhibitor
Name:
BDBM50297564
Synonyms:
CHEMBL550611 | N''-{6-fluoro-2-[(5-methoxy-1H-benzimidazol-2-yl)thio]-2,3-dihydro-1H-inden-1-ylidene}carbonohydrazonic diamide hydrochloride
Type:
Small organic molecule
Emp. Form.:
C18H17FN6OS
Mol. Mass.:
384.431
SMILES:
COc1ccc2nc(SC3Cc4ccc(F)cc4C3=NN=C(N)N)[nH]c2c1 |w:19.21,(24.92,-44.65,;24.93,-46.19,;26.26,-46.96,;26.26,-48.51,;27.59,-49.28,;28.93,-48.51,;30.41,-48.99,;31.32,-47.73,;32.86,-47.73,;33.64,-49.06,;33.01,-50.46,;34.16,-51.49,;34.16,-53.02,;35.48,-53.79,;36.82,-53.02,;38.15,-53.78,;36.81,-51.49,;35.49,-50.72,;35.17,-49.22,;36.2,-48.07,;37.7,-48.38,;38.73,-47.23,;40.24,-47.55,;38.25,-45.77,;30.41,-46.47,;28.93,-46.95,;27.59,-46.19,)|
Structure:
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