Reaction Details 
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Glucagon-like peptide 1 receptor
Ligand
BDBM50301942
Substrate
n/a
Meas. Tech.
ChEMBL_598670 (CHEMBL1048996)
EC50
95±n/a nM
Citation
Mapelli, C; Natarajan, SI; Meyer, JP; Bastos, MM; Bernatowicz, MS; Lee, VG; Pluscec, J; Riexinger, DJ; Sieber-McMaster, ES; Constantine, KL; Smith-Monroy, CA; Golla, R; Ma, Z; Longhi, DA; Shi, D; Xin, L; Taylor, JR; Koplowitz, B; Chi, CL; Khanna, A; Robinson, GW; Seethala, R; Antal-Zimanyi, IA; Stoffel, RH; Han, S; Whaley, JM; Huang, CS; Krupinski, J; Ewing, WR Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity. J Med Chem 52:7788-99 (2009) [PubMed] ArticleMore Info.:
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
Inhibitor
Name:
BDBM50301942
Synonyms:
(3S,6S,9S,12S,15S,21S)-21-((S)-2-((S)-2-amino-3-(1H-imidazol-5-yl)propanamido)propanamido)-3-((S)-1-((S)-1-amino-3-(4'-methylbiphenyl-4-yl)-1-oxopropan-2-ylamino)-3-(2'-methylbiphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)-12-benzyl-9,15-bis((R)-1-hydroxyethyl)-6-(hydroxymethyl)-5,8,11,14,17,20-hexaoxo-4,7,10,13,16,19-hexaazatetracosane-1,24-dioic acid | CHEMBL576916
Type:
Small organic molecule
Emp. Form.:
C72H88N14O18
Mol. Mass.:
1437.5521
SMILES:
C[C@@H](O)[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1C)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(C)cc1)C(N)=O |r|
Structure:
