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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50309190
Substrate
n/a
Meas. Tech.
ChEMBL_608809 (CHEMBL1068401)
IC50
2500±n/a nM
Citation
 Hilton, S; Naud, S; Caldwell, JJ; Boxall, K; Burns, S; Anderson, VE; Antoni, L; Allen, CE; Pearl, LH; Oliver, AW; Wynne Aherne, G; Garrett, MD; Collins, I Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2. Bioorg Med Chem 18:707-18 (2010) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50309190
Synonyms:
2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)-N-[2-(DIMETHYLAMINO)ETHYL]PYRIDINE-3-CARBOXAMIDE | 2-Amino-5-(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-N-(2-(dimethylamino)ethyl)nicotinamide | CHEMBL598973
Type:
Small organic molecule
Emp. Form.:
C16H20N4O3S
Mol. Mass.:
348.42
SMILES:
CN(C)CCNC(=O)c1cc(cnc1N)-c1scc2OCCOc12
Structure:
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