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Target
Translocator protein
Ligand
BDBM50310140
Substrate
n/a
Meas. Tech.
ChEMBL_612729 (CHEMBL1069601)
Ki
12±n/a nM
Citation
 Stevenson, L; Tavares, AA; Brunet, A; McGonagle, FI; Dewar, D; Pimlott, SL; Sutherland, A New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein. Bioorg Med Chem Lett 20:954-7 (2010) [PubMed]  Article
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50310140
Synonyms:
CHEMBL605154 | N,N-Diethyl-3-iodomethyl-4-phenylquinoline-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C21H21IN2O
Mol. Mass.:
444.3087
SMILES:
CCN(CC)C(=O)c1nc2ccccc2c(-c2ccccc2)c1CI
Structure:
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