Reaction Details  Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50378721
Substrate
n/a
Meas. Tech.
ChEMBL_627491 (CHEMBL1111777)
Ki
9.39±n/a nM
Citation
 Efange, SM; Khare, AB; von Hohenberg, K; Mach, RH; Parsons, SM; Tu, Z Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter. J Med Chem 53:2825-35 (2010) [PubMed]  Article
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50378721
Synonyms:
CHEMBL1204035
Type:
Small organic molecule
Emp. Form.:
C16H22INO2S
Mol. Mass.:
419.321
SMILES:
O[C@@H]1CCCC[C@H]1N1CCC(CC1)C(=O)c1ccc(I)s1 |r|
Structure:
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