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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50226002
Substrate
n/a
Meas. Tech.
ChEMBL_631176 (CHEMBL1109110)
IC50
>1000000±n/a nM
Citation
 McKenna, CE; Kashemirov, BA; Blazewska, KM; Mallard-Favier, I; Stewart, CA; Rojas, J; Lundy, MW; Ebetino, FH; Baron, RA; Dunford, JE; Kirsten, ML; Seabra, MC; Bala, JL; Marma, MS; Rogers, MJ; Coxon, FP Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem 53:3454-64 (2010) [PubMed]  Article
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Homo sapiens (Human)
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM50226002
Synonyms:
(R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid | 2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid | 3-(3-Pyridyl)-2-hydroxy-2-phosphonopropanoic acid | CHEMBL397829
Type:
Small organic molecule
Emp. Form.:
C8H10NO6P
Mol. Mass.:
247.1419
SMILES:
OC(=O)C(O)(Cc1cccnc1)P(O)(O)=O
Structure:
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