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Target
Methionine aminopeptidase 1
Ligand
BDBM50180737
Substrate
n/a
Meas. Tech.
ChEMBL_639876 (CHEMBL1173891)
IC50
32600±n/a nM
Citation
 Altmeyer, MA; Marschner, A; Schiffmann, R; Klein, CD Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors. Bioorg Med Chem Lett 20:4038-44 (2010) [PubMed]  Article
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM50180737
Synonyms:
5,6-dimethyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole | 5,6-dimethyl-2-pyridin-2-yl-1H-benzoimidazole | CHEMBL371956 | US8748618, LD-1-37
Type:
Small organic molecule
Emp. Form.:
C14H13N3
Mol. Mass.:
223.2731
SMILES:
Cc1cc2nc([nH]c2cc1C)-c1ccccn1
Structure:
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