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Target
Methionine aminopeptidase 1
Ligand
BDBM50180754
Substrate
n/a
Meas. Tech.
ChEMBL_639876 (CHEMBL1173891)
IC50
41000±n/a nM
Citation
 Altmeyer, MA; Marschner, A; Schiffmann, R; Klein, CD Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors. Bioorg Med Chem Lett 20:4038-44 (2010) [PubMed]  Article
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM50180754
Synonyms:
CHEMBL199461 | phenyl(2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-yl)methanone | phenyl-(2-thiazol-4-yl-1H-benzoimidazol-5-yl)-methanone
Type:
Small organic molecule
Emp. Form.:
C17H11N3OS
Mol. Mass.:
305.354
SMILES:
O=C(c1ccccc1)c1ccc2nc([nH]c2c1)-c1cscn1
Structure:
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