Reaction Details  Report a problem with these data
Target
Methionine aminopeptidase 1
Ligand
BDBM50180751
Substrate
n/a
Meas. Tech.
ChEMBL_639876 (CHEMBL1173891)
IC50
28800±n/a nM
Citation
 Altmeyer, MA; Marschner, A; Schiffmann, R; Klein, CD Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors. Bioorg Med Chem Lett 20:4038-44 (2010) [PubMed]  Article
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM50180751
Synonyms:
5-nitro-2-(pyridin-2-yl)-1H-benzo[d]imidazole | 5-nitro-2-pyridin-2-yl-1(3)H-benzoimidazole | CHEMBL380979
Type:
Small organic molecule
Emp. Form.:
C12H8N4O2
Mol. Mass.:
240.2175
SMILES:
[O-][N+](=O)c1ccc2nc([nH]c2c1)-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: