Reaction Details  Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50326569
Substrate
n/a
Meas. Tech.
ChEMBL_661809 (CHEMBL1252125)
IC50
28400±n/a nM
Citation
 El Turk, F; Fauvet, B; Ouertatani-Sakouhi, H; Lugari, A; Betzi, S; Roche, P; Morelli, X; Lashuel, HA An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem 18:5425-40 (2010) [PubMed]  Article
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50326569
Synonyms:
CHEMBL1253492 | methyl 2-(4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-ylthio)acetate
Type:
Small organic molecule
Emp. Form.:
C10H11N3O2S2
Mol. Mass.:
269.343
SMILES:
COC(=O)CSc1nnc(-c2cccs2)n1C
Structure:
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