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Target
Histone deacetylase 1
Ligand
BDBM50350825
Substrate
n/a
Meas. Tech.
ChEMBL_763305 (CHEMBL1820399)
IC50
21±n/a nM
Citation
 Shultz, MD; Cao, X; Chen, CH; Cho, YS; Davis, NR; Eckman, J; Fan, J; Fekete, A; Firestone, B; Flynn, J; Green, J; Growney, JD; Holmqvist, M; Hsu, M; Jansson, D; Jiang, L; Kwon, P; Liu, G; Lombardo, F; Lu, Q; Majumdar, D; Meta, C; Perez, L; Pu, M; Ramsey, T; Remiszewski, S; Skolnik, S; Traebert, M; Urban, L; Uttamsingh, V; Wang, P; Whitebread, S; Whitehead, L; Yan-Neale, Y; Yao, YM; Zhou, L; Atadja, P Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors. J Med Chem 54:4752-72 (2011) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50350825
Synonyms:
CHEMBL1819265
Type:
Small organic molecule
Emp. Form.:
C19H20N4O2
Mol. Mass.:
336.3877
SMILES:
ONC(=O)C=Cc1ccc(CNCCc2c[nH]c3ccncc23)cc1 |w:5.5|
Structure:
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