Reaction Details  Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50380923
Substrate
n/a
Meas. Tech.
ChEMBL_813976 (CHEMBL2020488)
Ki
0.9±n/a nM
Citation
 Fichtner, M; Lee, E; Tomlinson, E; Scott, D; Cornelius, P; Patterson, TA; Carpino, PA Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett 22:2738-43 (2012) [PubMed]  Article
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50380923
Synonyms:
CHEMBL2016740
Type:
Small organic molecule
Emp. Form.:
C24H23N5O3
Mol. Mass.:
429.4711
SMILES:
CN([C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21)C(=O)Nc1cnc(cn1)-c1ccccc1 |r,wU:5.8,wD:2.1,(11.79,-13.56,;11.79,-15.1,;10.46,-15.87,;9.13,-15.1,;7.8,-15.86,;7.79,-17.4,;9.12,-18.18,;10.46,-17.41,;7.87,-18.94,;6.42,-19.49,;6.02,-20.97,;5.45,-18.29,;3.92,-18.2,;3.22,-16.83,;4.06,-15.53,;5.61,-15.62,;6.3,-17,;13.13,-15.87,;13.13,-17.41,;14.46,-15.1,;15.79,-15.87,;17.11,-15.1,;18.45,-15.86,;18.45,-17.41,;17.12,-18.18,;15.79,-17.41,;19.78,-18.17,;19.78,-19.72,;21.11,-20.48,;22.45,-19.71,;22.44,-18.17,;21.11,-17.41,)|
Structure:
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