Reaction Details  Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50382301
Substrate
n/a
Meas. Tech.
ChEMBL_816864 (CHEMBL2026135)
IC50
5.4±n/a nM
Citation
 Agai-Csongor, E; Domány, G; Nógrádi, K; Galambos, J; Vágó, I; Keseru, GM; Greiner, I; Laszlovszky, I; Gere, A; Schmidt, E; Kiss, B; Vastag, M; Tihanyi, K; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Kapás, M; Szombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett 22:3437-40 (2012) [PubMed]  Article
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50382301
Synonyms:
CHEMBL2024515
Type:
Small organic molecule
Emp. Form.:
C19H29Cl2N3O2S
Mol. Mass.:
434.423
SMILES:
CS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1 |r,wU:5.4,wD:8.8,(-1.04,-12.4,;.29,-11.63,;1.06,-10.3,;-.48,-10.29,;1.62,-12.4,;2.96,-11.63,;2.96,-10.09,;4.28,-9.31,;5.61,-10.09,;6.95,-9.32,;8.28,-10.1,;9.62,-9.33,;10.94,-10.11,;12.27,-9.35,;12.29,-7.81,;10.96,-7.03,;9.61,-7.79,;13.63,-7.05,;14.97,-7.79,;16.3,-6.99,;16.26,-5.45,;14.92,-4.72,;14.89,-3.18,;13.6,-5.51,;12.25,-4.76,;5.61,-11.63,;4.28,-12.39,)|
Structure:
Search PDB for entries with ligand similarity: