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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50383737
Substrate
n/a
Meas. Tech.
ChEMBL_819142 (CHEMBL2034662)
IC50
11±n/a nM
Citation
 Koltun, ES; Tsuhako, AL; Brown, DS; Aay, N; Arcalas, A; Chan, V; Du, H; Engst, S; Ferguson, K; Franzini, M; Galan, A; Holst, CR; Huang, P; Kane, B; Kim, MH; Li, J; Markby, D; Mohan, M; Noson, K; Plonowski, A; Richards, SJ; Robertson, S; Shaw, K; Stott, G; Stout, TJ; Young, J; Yu, P; Zaharia, CA; Zhang, W; Zhou, P; Nuss, JM; Xu, W; Kearney, PC Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett 22:3727-31 (2012) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50383737
Synonyms:
CHEMBL2030401
Type:
Small organic molecule
Emp. Form.:
C14H11BrFN3O2
Mol. Mass.:
352.158
SMILES:
F[C@@H]1CN[C@@H](C1)c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1 |r|
Structure:
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