Reaction Details  Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50386107
Substrate
n/a
Meas. Tech.
ChEMBL_824506 (CHEMBL2045251)
Ki
630.96±n/a nM
Citation
 Areias, F; Costa, M; Castro, M; Brea, J; Gregori-Puigjané, E; Proença, MF; Mestres, J; Loza, MI New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships. Eur J Med Chem 54:303-10 (2012) [PubMed]  Article
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50386107
Synonyms:
CHEMBL2042081
Type:
Small organic molecule
Emp. Form.:
C21H14FN5O3
Mol. Mass.:
403.366
SMILES:
COc1cccc2cc(C(=O)Nc3c(ncn3-c3ccc(F)cc3)C#N)c(=N)oc12
Structure:
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