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Target
Serine/threonine-protein kinase PAK 4
Ligand
BDBM50389115
Substrate
n/a
Meas. Tech.
ChEMBL_832969 (CHEMBL2066924)
EC50
21±n/a nM
Citation
 Guo, C; McAlpine, I; Zhang, J; Knighton, DD; Kephart, S; Johnson, MC; Li, H; Bouzida, D; Yang, A; Dong, L; Marakovits, J; Tikhe, J; Richardson, P; Guo, LC; Kania, R; Edwards, MP; Kraynov, E; Christensen, J; Piraino, J; Lee, J; Dagostino, E; Del-Carmen, C; Deng, YL; Smeal, T; Murray, BW Discovery of pyrroloaminopyrazoles as novel PAK inhibitors. J Med Chem 55:4728-39 (2012) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase PAK 4
Synonyms:
KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)
Type:
Protein
Mol. Mass.:
64098.01
Organism:
Homo sapiens (Human)
Description:
O96013
Residue:
591
Sequence:
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
  
Inhibitor
Name:
BDBM50389115
Synonyms:
CHEMBL2064560
Type:
Small organic molecule
Emp. Form.:
C26H30N6O2
Mol. Mass.:
458.5554
SMILES:
CN1CCN(C(C1)c1ccccc1)C(=O)N1Cc2c(NC(=O)c3ccccc3)[nH]nc2C1(C)C
Structure:
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