Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50337278
Substrate
n/a
Meas. Tech.
ChEMBL_835655 (CHEMBL2071766)
Ki
38±n/a nM
Citation
 Sechi, M; Innocenti, A; Pala, N; Rogolino, D; Carcelli, M; Scozzafava, A; Supuran, CT Inhibition ofa-class cytosolic human carbonic anhydrases I, II, IX and XII, andß-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors. Bioorg Med Chem Lett 22:5801-6 (2012) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50337278
Synonyms:
2-(phenylamino)benzoic acid | 2-Phenylamino-benzoic acid | CHEMBL23832 | N-phenylanthranilic acid | US9271961, 2 | phenylanthranilic acid
Type:
Small organic molecule
Emp. Form.:
C13H11NO2
Mol. Mass.:
213.2319
SMILES:
OC(=O)c1ccccc1Nc1ccccc1
Structure:
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