Reaction Details  Report a problem with these data
Target
Dual specificity protein phosphatase 4
Ligand
BDBM50391713
Substrate
n/a
Meas. Tech.
ChEMBL_848110 (CHEMBL2148511)
IC50
2290±n/a nM
Citation
 Park, H; Chien, PN; Ryu, SE Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening. Bioorg Med Chem Lett 22:6333-7 (2012) [PubMed]  Article
Target
Name:
Dual specificity protein phosphatase 4
Synonyms:
DUS4_HUMAN | DUSP4 | Dual specificity protein phosphatase hVH2 | MAP kinase phosphatase 2 | MKP-2 | MKP2 | Mitogen-activated protein kinase phosphatase 2 | VH2
Type:
PROTEIN
Mol. Mass.:
42957.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_848110
Residue:
394
Sequence:
MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC
  
Inhibitor
Name:
BDBM50391713
Synonyms:
CHEMBL2146956
Type:
Small organic molecule
Emp. Form.:
C16H9N7S
Mol. Mass.:
331.355
SMILES:
c1ccc2nc(ccc2c1)-c1nnc2sc(nn12)-c1cnccn1
Structure:
Search PDB for entries with ligand similarity: