Reaction Details  Report a problem with these data
Target
Protein tyrosine phosphatase type IVA 3
Ligand
BDBM50391711
Substrate
n/a
Meas. Tech.
ChEMBL_848112 (CHEMBL2148513)
IC50
11000±n/a nM
Citation
 Park, H; Chien, PN; Ryu, SE Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening. Bioorg Med Chem Lett 22:6333-7 (2012) [PubMed]  Article
Target
Name:
Protein tyrosine phosphatase type IVA 3
Synonyms:
PRL3 | PTP4A3 | Protein-tyrosine phosphatase 4A3 | TP4A3_HUMAN
Type:
PROTEIN
Mol. Mass.:
19546.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461022
Residue:
173
Sequence:
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
  
Inhibitor
Name:
BDBM50391711
Synonyms:
CHEMBL2146958
Type:
Small organic molecule
Emp. Form.:
C16H10N2O3S
Mol. Mass.:
310.327
SMILES:
Oc1ccc(\C=c2/sc3nc4ccccc4n3c2=O)cc1O
Structure:
Search PDB for entries with ligand similarity: