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Target
Low molecular weight phosphotyrosine protein phosphatase
Ligand
BDBM50148911
Substrate
n/a
Meas. Tech.
ChEMBL_848285 (CHEMBL2149374)
IC50
11100±n/a nM
Citation
 Ramírez-Espinosa, JJ; Rios, MY; López-Martínez, S; López-Vallejo, F; Medina-Franco, JL; Paoli, P; Camici, G; Navarrete-Vázquez, G; Ortiz-Andrade, R; Estrada-Soto, S Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches. Eur J Med Chem 46:2243-51 (2011) [PubMed]  Article
Target
Name:
Low molecular weight phosphotyrosine protein phosphatase
Synonyms:
3.1.3.2 | 3.1.3.48 | ACP1 | Adipocyte acid phosphatase | LMW-PTP | LMW-PTPase | LMWPTP | Low molecular weight cytosolic acid phosphatase | PPAC_HUMAN | Red cell acid phosphatase 1 | low molecular weight phosphotyrosine protein phosphatase isoform c
Type:
n/a
Mol. Mass.:
18042.81
Organism:
Homo sapiens (Human)
Description:
P24666
Residue:
158
Sequence:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
  
Inhibitor
Name:
BDBM50148911
Synonyms:
(3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hydroxyurs-12-en-28-oic acid | CHEMBL169 | Ursolic acid | malol | prunol | urson
Type:
Small organic molecule
Emp. Form.:
C30H48O3
Mol. Mass.:
456.7003
SMILES:
C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O |r,c:9|
Structure:
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