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Target
Histamine H1 receptor
Ligand
BDBM50392761
Substrate
n/a
Meas. Tech.
ChEMBL_853257 (CHEMBL2154958)
Ki
2511.89±n/a nM
Citation
 Berlin, M; Boyce, CW; Ruiz Mde, L Histamine H3 receptor as a drug discovery target. J Med Chem 54:26-53 (2011) [PubMed]  Article
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50392761
Synonyms:
CHEMBL2151155
Type:
Small organic molecule
Emp. Form.:
C27H35N3O4S
Mol. Mass.:
497.65
SMILES:
CS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(CC1)c1ccc(OC2CCN(CC2)C2CCC2)cc1
Structure:
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