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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50392849
Substrate
n/a
Meas. Tech.
ChEMBL_853358 (CHEMBL2155148)
IC50
500±n/a nM
Citation
 Kaoud, TS; Yan, C; Mitra, S; Tseng, CC; Jose, J; Taliaferro, JM; Tuohetahuntila, M; Devkota, A; Sammons, R; Park, J; Park, H; Shi, Y; Hong, J; Ren, P; Dalby, KN From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules. ACS Med Chem Lett 3:721-725 (2012) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50392849
Synonyms:
CHEMBL2151190 | US9073941, 612
Type:
Small organic molecule
Emp. Form.:
C14H11N5O4
Mol. Mass.:
313.2682
SMILES:
Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc2OCOc2c1
Structure:
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