Reaction Details  Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50392875
Substrate
n/a
Meas. Tech.
ChEMBL_853333 (CHEMBL2155123)
EC50
1900±n/a nM
Citation
 Brown, SP; Dransfield, PJ; Vimolratana, M; Jiao, X; Zhu, L; Pattaropong, V; Sun, Y; Liu, J; Luo, J; Zhang, J; Wong, S; Zhuang, R; Guo, Q; Li, F; Medina, JC; Swaminath, G; Lin, DC; Houze, JB Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. ACS Med Chem Lett 3:726-730 (2012) [PubMed]  Article
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50392875
Synonyms:
CHEMBL2151291
Type:
Small organic molecule
Emp. Form.:
C23H21FO4
Mol. Mass.:
380.4088
SMILES:
COc1ccc(F)c(c1)-c1ccc(COc2ccc(CCC(O)=O)cc2)cc1
Structure:
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