Reaction Details  Report a problem with these data
Target
Dual specificity protein kinase CLK2
Ligand
BDBM50292406
Substrate
n/a
Meas. Tech.
ChEMBL_875431 (CHEMBL2182298)
IC50
2100±n/a nM
Citation
 Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem 55:9312-30 (2012) [PubMed]  Article
Target
Name:
Dual specificity protein kinase CLK2
Synonyms:
CDC-like kinase 2 | CLK2_MOUSE | Clk2
Type:
PROTEIN
Mol. Mass.:
60021.57
Organism:
Mus musculus
Description:
ChEMBL_1502246
Residue:
499
Sequence:
MPHPRRYHSSERGSRGSYHEHYQSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDHSSDRRLYDRRYCGSYRRNDYSRDRGEAYYDTDFRQSYEYHRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGTQVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFFACLRTEPPNTKLWDSSRDISR
  
Inhibitor
Name:
BDBM50292406
Synonyms:
CHEMBL485053 | leucettamine B
Type:
Small organic molecule
Emp. Form.:
C12H11N3O3
Mol. Mass.:
245.234
SMILES:
CN1C(N)=NC(=Cc2ccc3OCOc3c2)C1=O |w:6.6,c:3|
Structure:
Search PDB for entries with ligand similarity: