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Target
Casein kinase I isoform alpha
Ligand
BDBM50400756
Substrate
n/a
Meas. Tech.
ChEMBL_880534 (CHEMBL2211469)
IC50
225±n/a nM
Citation
 Huang, H; Acquaviva, L; Berry, V; Bregman, H; Chakka, N; DiMauro, EF; Dovey, J; Epstein, O; Grubinska, B; Goldstein, J; Gunaydin, H; Hua, Z; Huang, X; Huang, L; Human, J; Long, A; Newcomb, J; Patel, VF; Saffran, D; Serafino, R; Schneider, S; Strathdee, C; Tang, J; Turci, S; White, R; Yu, V; Zhao, H; Wilson, C; Martin, MW Structure-Based Design of Potent and Selective CK1¿ Inhibitors. ACS Med Chem Lett 3:1059-1064 (2012) [PubMed]  Article
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM50400756
Synonyms:
CHEMBL2203562
Type:
Small organic molecule
Emp. Form.:
C20H17F2N3O3
Mol. Mass.:
385.3641
SMILES:
COc1cnc(COc2ccc(F)cc2F)cc1-c1cc2c(CCNC2=O)[nH]1
Structure:
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