Target
Leukotriene A-4 hydrolase
Ligand
BDBM50402383
Substrate
n/a
Meas. Tech.
ChEMBL_886318 (CHEMBL2212808)
IC50
5±n/a nM
Citation
 Tanis, VMBacani, GMBlevitt, JMChrovian, CCCrawford, SDe Leon, AFourie, AMGomez, LGrice, CAHerman, KKearney, AMLandry-Bayle, AMLee-Dutra, ANelson, JRiley, JPSantillán, AWiener, JJXue, XYoung, AL Azabenzthiazole inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem Lett 22:7504-11 (2012) [PubMed]  Article
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50402383
Synonyms:
CHEMBL2207750
Type:
Small organic molecule
Emp. Form.:
C20H20N4O2S
Mol. Mass.:
380.463
SMILES:
CC(=O)N1CC2CC1CN2Cc1ccc(Oc2nc3ncccc3s2)cc1 |THB:10:9:6:4.3,1:3:8.9:6|
Structure:
Search PDB for entries with ligand similarity: