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Target
Leukotriene A-4 hydrolase
Ligand
BDBM50402396
Substrate
n/a
Meas. Tech.
ChEMBL_886318 (CHEMBL2212808)
IC50
16±n/a nM
Citation
 Tanis, VM; Bacani, GM; Blevitt, JM; Chrovian, CC; Crawford, S; De Leon, A; Fourie, AM; Gomez, L; Grice, CA; Herman, K; Kearney, AM; Landry-Bayle, AM; Lee-Dutra, A; Nelson, J; Riley, JP; Santillán, A; Wiener, JJ; Xue, X; Young, AL Azabenzthiazole inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem Lett 22:7504-11 (2012) [PubMed]  Article
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50402396
Synonyms:
CHEMBL2207737
Type:
Small organic molecule
Emp. Form.:
C20H22N4O3S
Mol. Mass.:
398.479
SMILES:
NC(=O)C1CCN(CCOc2ccc(Oc3nc4ncccc4s3)cc2)CC1
Structure:
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