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Target
Hexokinase-4
Ligand
BDBM50402950
Substrate
n/a
Meas. Tech.
ChEMBL_885336 (CHEMBL2215199)
EC50
>100000±n/a nM
Citation
 Bonn, P; Brink, DM; Fägerhag, J; Jurva, U; Robb, GR; Schnecke, V; Svensson Henriksson, A; Waring, MJ; Westerlund, C The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold. Bioorg Med Chem Lett 22:7302-5 (2012) [PubMed]  Article
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50402950
Synonyms:
CHEMBL2206775
Type:
Small organic molecule
Emp. Form.:
C17H14N6OS2
Mol. Mass.:
382.463
SMILES:
Cc1csc(NC(=O)CSc2ncnc3n(ncc23)-c2ccccc2)n1
Structure:
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