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Target
Hexokinase-4
Ligand
BDBM50402954
Substrate
n/a
Meas. Tech.
ChEMBL_885336 (CHEMBL2215199)
EC50
316.23±n/a nM
Citation
 Bonn, P; Brink, DM; Fägerhag, J; Jurva, U; Robb, GR; Schnecke, V; Svensson Henriksson, A; Waring, MJ; Westerlund, C The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold. Bioorg Med Chem Lett 22:7302-5 (2012) [PubMed]  Article
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50402954
Synonyms:
CHEMBL2206787
Type:
Small organic molecule
Emp. Form.:
C23H24N6O3
Mol. Mass.:
432.4751
SMILES:
COCCC(Oc1ncnc2n(ncc12)-c1ccccc1C)C(=O)Nc1ccc(C)cn1
Structure:
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