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Target
Collagenase 3
Ligand
BDBM50098284
Substrate
n/a
Meas. Tech.
ChEMBL_106465 (CHEMBL858330)
IC50
2754.23±n/a nM
Citation
 Sarma, JA; Rambabu, G; Srikanth, K; Raveendra, D; Vithal, M Analogue based design of MMP-13 (Collagenase-3) inhibitors. Bioorg Med Chem Lett 12:2689-93 (2002) [PubMed]
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM50098284
Synonyms:
6-(4-Methanesulfonyl-piperazin-1-yl)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-hex-4-ynoic acid | CHEMBL275345
Type:
Small organic molecule
Emp. Form.:
C24H29N3O7S2
Mol. Mass.:
535.633
SMILES:
COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC(CC#CCN1CCN(CC1)S(C)(=O)=O)C(O)=O
Structure:
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