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Target
Collagenase 3
Ligand
BDBM50098272
Substrate
n/a
Meas. Tech.
ChEMBL_106465 (CHEMBL858330)
IC50
489.78±n/a nM
Citation
 Sarma, JA; Rambabu, G; Srikanth, K; Raveendra, D; Vithal, M Analogue based design of MMP-13 (Collagenase-3) inhibitors. Bioorg Med Chem Lett 12:2689-93 (2002) [PubMed]
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM50098272
Synonyms:
5-Phenyl-2-(4-phenylazo-benzenesulfonylamino)-pent-4-ynoic acid | CHEMBL274174
Type:
Small organic molecule
Emp. Form.:
C23H19N3O4S
Mol. Mass.:
433.48
SMILES:
OC(=O)C(CC#Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)\N=N\c1ccccc1
Structure:
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