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Target
Beta-2 adrenergic receptor
Ligand
BDBM50416057
Substrate
n/a
Meas. Tech.
ChEMBL_634432 (CHEMBL1119458)
EC50
2.5±n/a nM
Citation
 Procopiou, PA; Barrett, VJ; Bevan, NJ; Biggadike, K; Box, PC; Butchers, PR; Coe, DM; Conroy, R; Emmons, A; Ford, AJ; Holmes, DS; Horsley, H; Kerr, F; Li-Kwai-Cheung, AM; Looker, BE; Mann, IS; McLay, IM; Morrison, VS; Mutch, PJ; Smith, CE; Tomlin, P Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach. J Med Chem 53:4522-30 (2010) [PubMed]  Article
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50416057
Synonyms:
CHEMBL1085395
Type:
Small organic molecule
Emp. Form.:
C24H35NO5
Mol. Mass.:
417.5384
SMILES:
OCc1cc(ccc1O)[C@@H](O)CNCCCCCCOCCOCc1ccccc1 |r|
Structure:
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