Reaction Details  Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50416303
Substrate
n/a
Meas. Tech.
ChEMBL_640105 (CHEMBL1174375)
Ki
125.89±n/a nM
Citation
 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R Identification of a sulfonamide series of CCR2 antagonists. Bioorg Med Chem Lett 20:3961-4 (2010) [PubMed]  Article
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50416303
Synonyms:
CHEMBL1170391
Type:
Small organic molecule
Emp. Form.:
C20H12ClF4NO5S
Mol. Mass.:
489.825
SMILES:
OC(=O)c1c(F)cccc1Oc1ccc(cc1NS(=O)(=O)c1ccc(Cl)cc1)C(F)(F)F
Structure:
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