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Target
Acetylcholine-binding protein
Ligand
BDBM50419751
Substrate
n/a
Meas. Tech.
ChEMBL_801486 (CHEMBL1948413)
Ki
1995.26±n/a nM
Citation
 Edink, E; Akdemir, A; Jansen, C; van Elk, R; Zuiderveld, O; de Kanter, FJ; van Muijlwijk-Koezen, JE; Smit, AB; Leurs, R; de Esch, IJ Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein. Bioorg Med Chem Lett 22:1448-54 (2012) [PubMed]  Article
Target
Name:
Acetylcholine-binding protein
Synonyms:
ACHP_LYMST | ACh-binding protein | Acetylcholine Binding protein | Acetylcholine-binding protein (AchBP) | Acetylcholine-binding protein (Ls-AchBP) | AchBP
Type:
n/a
Mol. Mass.:
26055.52
Organism:
Lymnaea stagnalis
Description:
Soluble acetylcholine receptor
Residue:
229
Sequence:
MRRNIFCLACLWIVQACLSLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSEIL
  
Inhibitor
Name:
BDBM50419751
Synonyms:
DEPTROPINE
Type:
Small organic molecule
Emp. Form.:
C23H27NO
Mol. Mass.:
333.4666
SMILES:
CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC1c2ccccc2CCc2ccccc12 |TLB:0:1:7.8.6:4.3,THB:9:7:1:4.3|
Structure:
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