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Target
Beta-1 adrenergic receptor
Ligand
BDBM50421330
Substrate
n/a
Meas. Tech.
ChEMBL_841416 (CHEMBL2091585)
Ki
133±n/a nM
Citation
 Beattie, D; Beer, D; Bradley, ME; Bruce, I; Charlton, SJ; Cuenoud, BM; Fairhurst, RA; Farr, D; Fozard, JR; Janus, D; Rosethorne, EM; Sandham, DA; Sykes, DA; Trifilieff, A; Turner, KL; Wissler, E An investigation into the structure-activity relationships associated with the systematic modification of theß(2)-adrenoceptor agonist indacaterol. Bioorg Med Chem Lett 22:6280-5 (2012) [PubMed]  Article
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50421330
Synonyms:
CHEMBL2088202
Type:
Small organic molecule
Emp. Form.:
C24H30N2O3
Mol. Mass.:
394.5066
SMILES:
CCC1=C(CC)CC2=C(CC(C2)NC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)C1 |r,c:2,t:7|
Structure:
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