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Target
Beta-2 adrenergic receptor
Ligand
BDBM50421326
Substrate
n/a
Meas. Tech.
ChEMBL_841421 (CHEMBL2091590)
IC50
240±n/a nM
Citation
 Beattie, D; Beer, D; Bradley, ME; Bruce, I; Charlton, SJ; Cuenoud, BM; Fairhurst, RA; Farr, D; Fozard, JR; Janus, D; Rosethorne, EM; Sandham, DA; Sykes, DA; Trifilieff, A; Turner, KL; Wissler, E An investigation into the structure-activity relationships associated with the systematic modification of theß(2)-adrenoceptor agonist indacaterol. Bioorg Med Chem Lett 22:6280-5 (2012) [PubMed]  Article
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2_CAVPO | Adrb2 | adrenergic Beta2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46993.24
Organism:
GUINEA PIG
Description:
adrenergic Beta2 ADRB2 GUINEA PIG::Q8K4Z4
Residue:
418
Sequence:
MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
  
Inhibitor
Name:
BDBM50421326
Synonyms:
CHEMBL2088198
Type:
Small organic molecule
Emp. Form.:
C24H28N2O2
Mol. Mass.:
376.4913
SMILES:
CCc1cc2CC(Cc2cc1CC)NCCc1ccc(O)c2[nH]c(=O)ccc12
Structure:
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