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Target
Histone deacetylase 1
Ligand
BDBM50421335
Substrate
n/a
Meas. Tech.
ChEMBL_840421 (CHEMBL2089598)
IC50
84000±n/a nM
Citation
 Liao, V; Liu, T; Codd, R Amide-based derivatives ofß-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects. Bioorg Med Chem Lett 22:6200-4 (2012) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50421335
Synonyms:
CHEMBL2088204
Type:
Small organic molecule
Emp. Form.:
C12H16N2O4
Mol. Mass.:
252.2664
SMILES:
Cc1ccc(OCC(=O)NCCC(=O)NO)cc1
Structure:
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