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Target
Neuropeptide Y receptor type 1
Ligand
BDBM50422838
Substrate
n/a
Meas. Tech.
ChEMBL_339377 (CHEMBL867214)
IC50
170±n/a nM
Citation
 Di Fabio, R; Giovannini, R; Bertani, B; Borriello, M; Bozzoli, A; Donati, D; Falchi, A; Ghirlanda, D; Leslie, CP; Pecunioso, A; Rumboldt, G; Spada, S Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists. Bioorg Med Chem Lett 16:1749-52 (2006) [PubMed]  Article
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50422838
Synonyms:
CHEMBL383763
Type:
Small organic molecule
Emp. Form.:
C30H36ClFN4O2
Mol. Mass.:
539.084
SMILES:
CN1CCN(CC1)C1C[C@@H](Oc2ccc(Cl)cc2)c2c(C1=O)c1ccccc1n2C[C@@H]1CCN(C)C[C@@H]1F
Structure:
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