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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Ligand
BDBM50425690
Substrate
n/a
Meas. Tech.
ChEMBL_937517 (CHEMBL2320503)
IC50
2890±n/a nM
Citation
 Poondra, RR; Nallamelli, RV; Meda, CL; Srinivas, BN; Grover, A; Muttabathula, J; Voleti, SR; Sridhar, B; Pal, M; Parsa, KV Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors. Bioorg Med Chem Lett 23:1104-9 (2013) [PubMed]  Article
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D
Type:
Protein
Mol. Mass.:
91092.69
Organism:
Homo sapiens (Human)
Description:
Q08499
Residue:
809
Sequence:
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM50425690
Synonyms:
CHEMBL2315896
Type:
Small organic molecule
Emp. Form.:
C26H28N2O8
Mol. Mass.:
496.5091
SMILES:
CCOC(=O)C1=CN(Cc2ccc(OC)c(OC)c2)C=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCC |c:20,t:5|
Structure:
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