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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50426356
Substrate
n/a
Meas. Tech.
ChEMBL_939924 (CHEMBL2327306)
Ki
49±n/a nM
Citation
 Brown, DG; Bernstein, PR; Wu, Y; Urbanek, RA; Becker, CW; Throner, SR; Dembofsky, BT; Steelman, GB; Lazor, LA; Scott, CW; Wood, MW; Wesolowski, SS; Nugiel, DA; Koch, S; Yu, J; Pivonka, DE; Li, S; Thompson, C; Zacco, A; Elmore, CS; Schroeder, P; Liu, J; Hurley, CA; Ward, S; Hunt, HJ; Williams, K; McLaughlin, J; Hoesch, V; Sydserff, S; Maier, D; Aharony, D Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. ACS Med Chem Lett 4:46-51 (2013) [PubMed]  Article
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50426356
Synonyms:
CHEMBL2321990
Type:
Small organic molecule
Emp. Form.:
C14H19Cl2NO
Mol. Mass.:
288.213
SMILES:
OCC[C@]1(CCCCNC1)c1ccc(Cl)c(Cl)c1 |r|
Structure:
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