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Target
Bcl-2-like protein 1
Ligand
BDBM50426415
Substrate
n/a
Meas. Tech.
ChEMBL_940156 (CHEMBL2328209)
IC50
115±n/a nM
Citation
 Touré, BB; Miller-Moslin, K; Yusuff, N; Perez, L; Doré, M; Joud, C; Michael, W; DiPietro, L; van der Plas, S; McEwan, M; Lenoir, F; Hoe, M; Karki, R; Springer, C; Sullivan, J; Levine, K; Fiorilla, C; Xie, X; Kulathila, R; Herlihy, K; Porter, D; Visser, M The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions. ACS Med Chem Lett 4:186-90 (2013) [PubMed]  Article
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50426415
Synonyms:
CHEMBL2326747
Type:
Small organic molecule
Emp. Form.:
C45H51ClF3N7O4S3
Mol. Mass.:
942.574
SMILES:
CC(N1CCC(CC1)N1CCc2c(C1)ncnc2NS(=O)(=O)c1ccc(N[C@H](CCN(C)C)CSc2ccccc2)c(c1)S(=O)(=O)C(F)(F)F)c1ccccc1-c1ccc(Cl)cc1 |r|
Structure:
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