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Target
Macrophage metalloelastase
Ligand
BDBM50427868
Substrate
n/a
Meas. Tech.
ChEMBL_940800 (CHEMBL2330328)
IC50
44±n/a nM
Citation
 Casalini, F; Fugazza, L; Esposito, G; Cabella, C; Brioschi, C; Cordaro, A; D'Angeli, L; Bartoli, A; Filannino, AM; Gringeri, CV; Longo, DL; Muzio, V; Nuti, E; Orlandini, E; Figlia, G; Quattrini, A; Tei, L; Digilio, G; Rossello, A; Maiocchi, A Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography. J Med Chem 56:2676-89 (2013) [PubMed]  Article
Target
Name:
Macrophage metalloelastase
Synonyms:
HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:
Enzyme
Mol. Mass.:
54012.99
Organism:
Homo sapiens (Human)
Description:
P39900
Residue:
470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
  
Inhibitor
Name:
BDBM50427868
Synonyms:
CHEMBL2326366
Type:
Small organic molecule
Emp. Form.:
C22H19FO5S
Mol. Mass.:
414.447
SMILES:
OC(=O)Cc1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccc(OCCF)cc1
Structure:
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