Reaction Details  Report a problem with these data
Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50430582
Substrate
n/a
Meas. Tech.
ChEMBL_946805 (CHEMBL2345024)
IC50
1600±n/a nM
Citation
 Wang, ZG; Chen, L; Chen, J; Zheng, JF; Gao, W; Zeng, Z; Zhou, H; Zhang, XK; Huang, PQ; Su, Y Synthesis and SAR study of modulators inhibiting tRXRa-dependent AKT activation. Eur J Med Chem 62:632-48 (2013) [PubMed]  Article
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50430582
Synonyms:
CHEMBL2337792
Type:
Small organic molecule
Emp. Form.:
C21H19FO2
Mol. Mass.:
322.3728
SMILES:
CC(C)c1ccc(\C=C2/C=C(CC(O)=O)c3cc(F)ccc23)cc1 |t:9|
Structure:
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