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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
Ligand
BDBM50431015
Substrate
n/a
Meas. Tech.
ChEMBL_947323 (CHEMBL2344107)
IC50
9800±n/a nM
Citation
 Aik, W; Demetriades, M; Hamdan, MK; Bagg, EA; Yeoh, KK; Lejeune, C; Zhang, Z; McDonough, MA; Schofield, CJ Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem 56:3680-8 (2013) [PubMed]  Article
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase FTO
Synonyms:
FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752
Type:
PROTEIN
Mol. Mass.:
58263.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515854
Residue:
505
Sequence:
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP
  
Inhibitor
Name:
BDBM50431015
Synonyms:
CHEMBL2338329 | US10889546, FG-4592 | US9115085, Compound A Form A | US9340511, 3
Type:
Small organic molecule
Emp. Form.:
C19H16N2O5
Mol. Mass.:
352.3407
SMILES:
Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccccc3)cc12
Structure:
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