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Target
Atypical chemokine receptor 3
Ligand
BDBM50434052
Substrate
n/a
Meas. Tech.
ChEMBL_958224 (CHEMBL2384567)
IC50
6190±n/a nM
Citation
 Yoshikawa, Y; Oishi, S; Kubo, T; Tanahara, N; Fujii, N; Furuya, T Optimized method of G-protein-coupled receptor homology modeling: its application to the discovery of novel CXCR7 ligands. J Med Chem 56:4236-51 (2013) [PubMed]  Article
Target
Name:
Atypical chemokine receptor 3
Synonyms:
ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1
Type:
Enzyme
Mol. Mass.:
41498.84
Organism:
Homo sapiens (Human)
Description:
P25106
Residue:
362
Sequence:
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
  
Inhibitor
Name:
BDBM50434052
Synonyms:
CHEMBL2381218
Type:
Small organic molecule
Emp. Form.:
C24H26FN3O2S
Mol. Mass.:
439.546
SMILES:
CCN1CCCC1CNC(=O)CN1C(=O)\C(Sc2ccccc12)=C\c1ccccc1F
Structure:
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