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Target
Protein tyrosine phosphatase type IVA 3
Ligand
BDBM50436447
Substrate
n/a
Meas. Tech.
ChEMBL_967878 (CHEMBL2400558)
IC50
800±n/a nM
Citation
 Min, G; Lee, SK; Kim, HN; Han, YM; Lee, RH; Jeong, DG; Han, DC; Kwon, BM Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells. Bioorg Med Chem Lett 23:3769-74 (2013) [PubMed]  Article
Target
Name:
Protein tyrosine phosphatase type IVA 3
Synonyms:
PRL3 | PTP4A3 | Protein-tyrosine phosphatase 4A3 | TP4A3_HUMAN
Type:
PROTEIN
Mol. Mass.:
19546.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461022
Residue:
173
Sequence:
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
  
Inhibitor
Name:
BDBM50436447
Synonyms:
CHEMBL2397162
Type:
Small organic molecule
Emp. Form.:
C20H17NO3S2
Mol. Mass.:
383.484
SMILES:
COc1ccccc1COc1ccccc1C=CC=C1SC(S)=NC1=O |w:16.17,18.19,c:24|
Structure:
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