Reaction Details  Report a problem with these data
Target
Protein tyrosine phosphatase type IVA 3
Ligand
BDBM50184288
Substrate
n/a
Meas. Tech.
ChEMBL_967878 (CHEMBL2400558)
IC50
1100±n/a nM
Citation
 Min, G; Lee, SK; Kim, HN; Han, YM; Lee, RH; Jeong, DG; Han, DC; Kwon, BM Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells. Bioorg Med Chem Lett 23:3769-74 (2013) [PubMed]  Article
Target
Name:
Protein tyrosine phosphatase type IVA 3
Synonyms:
PRL3 | PTP4A3 | Protein-tyrosine phosphatase 4A3 | TP4A3_HUMAN
Type:
PROTEIN
Mol. Mass.:
19546.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461022
Residue:
173
Sequence:
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
  
Inhibitor
Name:
BDBM50184288
Synonyms:
5-(2-(2-bromobenzyloxy)-5-bromobenzylidene)-2-thioxothiazolidin-4-one | CHEMBL207958
Type:
Small organic molecule
Emp. Form.:
C17H11Br2NO2S2
Mol. Mass.:
485.213
SMILES:
SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1Br |w:7.8,t:1|
Structure:
Search PDB for entries with ligand similarity: