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Target
Papain
Ligand
BDBM50436753
Substrate
n/a
Meas. Tech.
ChEMBL_971590 (CHEMBL2406864)
IC50
>50000±n/a nM
Citation
 Ettari, R; Tamborini, L; Angelo, IC; Micale, N; Pinto, A; De Micheli, C; Conti, P Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis. J Med Chem 56:5637-58 (2014) [PubMed]  Article
Target
Name:
Papain
Synonyms:
Allergen=Car p 1 | PAPA1_CARPA | PPI | Papaya proteinase I
Type:
Enzyme
Mol. Mass.:
38923.01
Organism:
Carica papaya
Description:
Papain was purchased from Sigma, Germany.
Residue:
345
Sequence:
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNEYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
  
Inhibitor
Name:
BDBM50436753
Synonyms:
CHEMBL2402107
Type:
Small organic molecule
Emp. Form.:
C17H14Cl2N2O3S
Mol. Mass.:
397.276
SMILES:
CCOC(=O)c1ccc(NC(=S)NC(=O)c2ccc(Cl)c(Cl)c2)cc1
Structure:
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